“A comprehensive and original opus linking metabolism with disease and preventative directions for the future. A must-read for experts and students alike ”
Michael Houghton PhD
2020 Nobel Laureate Medicine and Physiology
Professor at the Department of Medical Microbiology & Immunology
Li Ka Shing Applied Virology Institute,
University of Alberta
“Metabolism and Medicine by Dr. Brian Fertig is an unparalleled adventure into the fabric of physical law and medical impressionism, impelled by metaphysical questions and doubts to fashion new approaches to physiological questions in health and disease. This book is dense with science, synthesis, and interpretation, leaving the reader with just the right measure of resolve to learn even more. I strongly recommend Dr. Fertig’s opus for those still interrogating metabolism and medicine for satisfying answers.”
Jeffrey I. Mechanick, M.D., F.A.C.P., F.A.C.N., E.C.N.U., M.A.C.E.
Professor of Medicine; Medical Director, The Marie-Josee and Henry R. Kravis Center for Cardiovascular Health; Director, Metabolic Support, Division of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai. Prof. Mechanick served as: President of theAmerican College of Endocrinology, President of theAmericanAssociation of Clinical Endocrinologists, President of the American Board of Physician Nutrition Specialists, Member of the President’s Council on Fitness, Sports and Nutrition — Science Board. He is Editor-in-Chief Emeritus, President’s Council on Fitness, Sports and Nutrition Elevate Health, Chair, Board of Visitors, College of Computer, Mathematical, and Natural Sciences, University of Maryland, Chair, Physicians Engagement Committee, American Society for Parenteral and Enteral Nutrition.
“An insightful and comprehensive summary of the state of the field! This should appeal to both a novice as well as to an expert. Well written and authoritative in all areas”.
Philipp E. Scherer, PhD, Professor, Department of Internal Medicine, Gifford O. Touchstone Jr. and Randolph G. Touchstone, Distinguished Chair in Diabetes Research
Director, Touchstone Diabetes Center, Interim Chair, Department of Cell Biology, The University of Texas Southwestern Medical Center
(personal opinion, which does not express the views of the employer)
Dr. Philipp Scherer is the first scientist to win what could be called the “Triple Crown” of diabetes research recognition – adding the top Asian award (the 2018 Manpei Suzuki. International Prize for Diabetes Research) to the American and European ones in recognition of his discovery of adiponectin, a hormone released by fat cells, and subsequent research into the hormone’s role in fending off diabetes. His research has “deepened and widened our understanding of diabetes, obesity and energy homeostasis.”
“This transdisciplinary book beautifully tells the story of the dynamics of life in health and disease. In an unprecedented tour de force, Brian Fertig connects fundamental physicochemical mechanisms to the dynamics of metabolism. A mind-boggling book, for everyone to read!”
Bart Staels, PhD, Professor of Pharmacology (‘classe exceptionnelle’)
University Lille, Inserm, CHU de Lille, U1011-EGID, Institut Pasteur de Lille, France. Prof. Staels has been awarded the Young Investigator Award of the European Atherosclerosis Society, the Bronze Medal of the CNRS and the Lifetime Achievement Award of the British Atherosclerosis Society, the pharmaceutical “Barré” 2007 prize from the Faculté de Pharmacie of Montreal, and the French “JP Binet” prize from the Fondation pour la Recherche Médicale.
“Dr. Fertig elegantly captures the complexity of metabolism, showing us how our physiology is intimately integrated from the quantum level to the whole organism. Insightful, comprehensive, and thoughtful, these books will enlighten the beginner and expert alike!”
Steven D. Mittelman, MD, PhD, Chief, Division of Pediatric Endocrinology
Interim Chief, Division of Pediatric Genetics, Professor of Pediatrics
Solomon A. and Maria M. Kaplan Chair of Pediatric Endocrinology
UCLA Mattel Children’s Hospital, David Geffen School of Medicine
Prof. Mittelman served as the Fellowship Director and Director of the Keck/Caltech Combined MD/PhD Program
“Brian Fertig has melded a thought-provoking and eclectic blend of physics, physiology, psychology and philosophy into a highly original work of great scope and depth.”
Frederick S. Kaplan, M.D., Isaac & Rose Nassau Professor, Chief of the Division of Molecular Orthopaedic Medicine at the University of Pennsylvania School of Medicine. In 2006, the magazine Newsweek named Prof. Kaplan as one of their “15 People Who Make America Great”. In 2009, he was elected to the National Academy of Medicine. In 2017, Kaplan received the Rare Impact Award from the National Organization for Rare Disorders. In 2018, he received the Grand Hamdan International Award via the Sheikh Hamdan bin Rashid Al Maktoum Award for Medical Sciences for his work in medical sciences.
“This is a masterpiece!!! A truly unique point of view that should make all physicians THINK more as they care for their patients. I know you’ve been working hard for a long time on this and want to let you know – YOU’VE SUCCEEDED!”
Stan Schwartz, MD, Emeritus Associate Professor of Medicine at the University of Pennsylvania. He acted as mentor forEndocrinology, Diabetes and Metabolism Fellowship faculty members during Dr Fertig’s fellowship training at the University of Pennsylvania
“Before the Sars-COV2 pandemic enveloped the world, many who study metabolism, dismayed by the increasing prevalence of obesity and related diseases, observed an epidemiological transition from infectious to metabolic diseases. At the time of this writing, nearly 3 million people around the world have died from COVID19 and perhaps proving that aphorism false. But, we now know that obesity, insulin resistance and diabetes are important risk factors for developing severe COVID19 disease and, when the pandemic is contained, will remain important health concerns in nearly all countries. In these two volumes, Fertig has tackled the numerous complex pathways that comprise “metabolism”. Most scientists spend careers studying one of these pathways. Here, Fertig has compiled the work of many into a comprehensive work that is scholarly yet accessible. It is a love letter to the field, including important historical perspectives and key contributions of the physician scientists that have blazed the way. And, this work also provides an intricate framework with which to understand the coming tide of “-omic” data.”
Varman Samuel, MD, PhD, Associate Professor of Medicine (Endocrinology) at Yale University, Section Chief at VA Connecticut Healthcare System
“In Metabolism and Medicine, Brian Fertig provides an innovative, thought-provoking approach that unravels the pathophysiology of common metabolic diseases by relating them to basic physiochemical processes. A must read for everyone in the fields of Endocrinology, Diabetes, and Metabolism.”
Ralph A. DeFronzo, MD
Professor of Medicine
Chief, Diabetes Division
University of Texas Health Science Center
In 2008 he won the Banting Award from the ADA and the Claude Bernard Award from the European Association for the Study of Diabetes (EASD). The highest scientific awards given by the ADA and EASD. In 2017, Dr. DeFronzo won the Harold Hamm International Prize for Biomedical Research in Diabetes.
“Dr. Brian Fertig demonstrates a great talent for combining knowledge in biology and physics in a thought-provoking manner. Volume 1 of this book is about the legacy of physics in the dynamics of biological processes, as driven by the fundamental laws of conservation of free energy and the transfer of information. Volume 2 applies these laws to conceptualize a mathematical model of the physiological fitness landscape. It’s purpose is to invoke the notion of the fitness landscape, derived from physics, to physiology and Medicine for the purpose of a precision personalized scale of Medicine.
This innovative model is envisioned to highlight the relevance of physiological control, order, and response parameters that underpin energy economy, circadian clock synchronization and stress-management. The key towards understanding their intricate interaction is offered by examples showing that acute stressors can vitalize while chronic stress can devitalize.Chronic stress drives an energy demanding process, known as allostasis, to a point of criticality inexorably leading to the breakdown of adaptation and thus, enhancing vulnerability to disease.
It is envisioned that biomarkers combined with lifestyle factors and indices of willpower can inform network analytics with the goal of generating a physiological fitness landscape allowing educated predictions in healthy aging trajectories. The narrative is excellent and meant for readers interested in scenarios of a resilient life. The book features case studies and anecdotes, and is richly endowed with illustrations and summarizing captions, which all present a pleasant surprise to the innocent reader. Highly recommended!”
E. Ronald de Kloet, Academy Professor of Medical Pharmacology, Leiden University Medical Center, The Netherlands
Prof. de Kloet is a pioneer in the neuropsychopharmacology of stress hormones. He is Academy professor of the Royal Netherlands Academy of Arts and Sciences and the President of the Netherlands Endocrine Society (> 500 members). In the past he served as Chair of the Scientific Advisory Board of the Max Planck Institute for Psychiatry, Munich, Chair of theScientific Advisory Board of the Netherlands Institute for Brain Research. He served on the Advisory Board of the Institutes for Life Sciences of the Royal Netherlands Academy of Sciences. He serves on the editorial boards of: Psychoneuroendocrinology; Journal of Psychiatry Research; European Archives of Psychiatry and Clinical Neuroscience; Journal of Steroid Biochemistry & Molecular Biology; Frontiers in Neuroendocrinology, and in the past he was on the editorial Boards of: Journal of Neuroendocrinology, Stress (Editor-in-Chief and co-founder; Neuroendocrinology; Hormones & Behavior; Endocrinology; Journal ofNeuroscience Research.
“Dr. Fertig’s book is a must-read for anyone interested in gaining up-to-date knowledge about circadian optimization of human metabolism. In particular, the section on Circadian Biology, and the Biology of Time, captures the core of the chronophysiology perspective on human metabolism. These complex concepts are explained in a clear and cohesive fashion. The interdisciplinary metabolic perspective of biological time and aging is very engaging and provides an elucidating insight into this emerging field. This book has profound value to both researchers and clinicians.”
Satchidananda Panda, PhD, Professor, Salk Institute for Biological Studies
Prof. Panda is a pioneer in time restricted circadian eating patterns. He developed a smartphone application called myCircadianClock to assess eating patterns and implement time-restricted eating in human populations.
“This is a wonderful book providing a comprehensive overview of metabolism from biological processes to pathophysiology. Undoubted, it will interest both basic scientists and clinicians. It provides a wealth of information in a clear and highly readable format. I especially enjoyed reading chapter 8, which deals with the gut microbiota in health and disease. The chapter contains an enormous and highly readable account of this rapidly evolving area of research. The topic is of relevance to many disciplines including endocrinology, cardiology, neurology, psychiatry and immunology.”
Ted Dinan, PhD, Professor of Psychiatry at University College Cork, Ireland
Microbiome Alimentary Pharmacobiotic Center
Prof Dinan was Chair of Clinical Neurosciences and Professor of Psychological Medicine at St. Bartholomew’s Hospital, London. Prof. Dinan is a pioneer of gut microbiota research focusing on the influence of brain function and development including the regulation of the hypothalamic-pituitary-adrenal axis in situations of stress. He was awarded the Melvin Ramsey Prize for this research into the biology of stress.
“It is both intriguing and gratifying to see that the quantum theory of consciousness has influenced modern thinking about metabolic processes in important ways, as shown in Brian Fertig’s work. This book remarkably connects basic physiology to clinical medicine.”
Stuart Hameroff, University of Arizona
“A single author text is a rarity of late—especially one so comprehensive. These books combine text that is available to both novice and expert and provide insights to the history and personalities connected with discovery. Bravo to Dr. Fertig.”
Mark M. Rasenick
Distinguished Professor of Physiology & Biophysics and Psychiatry
Director, Biomedical Neuroscience Training Program
Research Career Scientist, Jesse Brown VAMC
U. Illinois Chicago College of Medicine
Dr Rasenick’s research, among many other contributions, was critical for the identification of G protein coupled receptors, the most pervasive and largest group of transmembrane receptors, important for hormonal and neurotransmitter signaling, physiology and behavior.